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Lookup NU author(s): Dr Ekaterina Yukhnovich, Dr Kai AlterORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025We introduce a novel modulation of broadband sounds which eliminates correlations between all frequency pairs close to the tinnitus frequency, to reduce cross-frequency neural synchrony and thereby quieten tinnitus. Fifty-three unselected participants completed a blinded randomised crossover trial, which was run completely online using their computers or smartphones, comparing active to perceptually-near-identical sham stimuli, comprising two 6-week listening periods and 3-week washout periods. Results showed a significant, persisting, reduction in self-rated tinnitus loudness after the active (p = 0.012), but not sham (p = 0.916) intervention. Tinnitus distress scores decreased in both listening periods, indicating tolerability of the intervention and trial process. Due to its automation, generalisability across tinnitus types, and deliverability with generic hardware, this intervention could be made available to most of the worldwide tinnitus community at minimal cost. Next steps involve optimising the intervention parameters to maximise efficacy, and development of a software package for wholescale delivery.
Author(s): Yukhnovich EA, Harrison S, Wray N, Alter K, Sedley W
Publication type: Article
Publication status: Published
Journal: Hearing Research
Year: 2025
Volume: 464
Print publication date: 01/08/2025
Online publication date: 08/06/2025
Acceptance date: 04/06/2025
Date deposited: 23/06/2025
ISSN (print): 0378-5955
ISSN (electronic): 1878-5891
Publisher: Elsevier B.V.
URL: https://doi.org/10.1016/j.heares.2025.109335
DOI: 10.1016/j.heares.2025.109335
Data Access Statement: Data is available using the following DOI: https://doi.org/10.25405/data.ncl.27109693
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