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Lookup NU author(s): Professor Andrew GenneryORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025. The understanding of autoinflammatory disorders, which are caused by the dysregulated activation of the innate immune system, has improved with the discovery of new diseases and the expansion of phenotypes. Inflammation can be controlled using immunosuppressive drugs, biological agents, and molecular-targeted therapies. However, some cases remain refractory to treatment, and certain patients experience side effects associated with the long-term use of corticosteroids. Recently, allogeneic hematopoietic cell transplantation (HCT) was reported to improve symptoms in refractory cases. Based on the previous reports, in this review, we discuss the potential of HCT in the treatment of autoinflammatory disorders.
Author(s): Kanegane H, Miyamoto S, Kamiya T, Ohnishi H, Nishikomori R, Gennery AR, Mori T
Publication type: Review
Publication status: Published
Journal: International Journal of Hematology
Year: 2025
Volume: 122
Pages: 190–198
Print publication date: 01/08/2025
Online publication date: 11/06/2025
Acceptance date: 27/05/2025
ISSN (print): 0925-5710
ISSN (electronic): 1865-3774
Publisher: Springer Nature
URL: https://doi.org/10.1007/s12185-025-04021-0
DOI: 10.1007/s12185-025-04021-0
Data Access Statement: The datasets for this article are not publicly available due to concerns regarding participant/patient anonymity. Requests to access the datasets should be directed to the corresponding author.
