Browse by author
Lookup NU author(s): Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025. Here, we investigated whether educational attainment influences the neurophysiological mechanisms underlying vigilance regulation, as reflected in resting-state eyes-closed electroencephalographic (rsEEG) rhythms, in patients with dementia due to Parkinson’s (PDD) and Lewy body disease (DLB). Clinical, demographic, and rsEEG data were obtained from an international database, including PDD patients (N = 75), DLB patients (N = 50), and cognitively unimpaired older controls (Healthy; N = 54). Each group was partitioned into low (Edu-) and high (Edu+) educational attainment subgroups, matched for age, sex, and cognitive-motor status. We analyzed rsEEG rhythms across the individual delta, theta, and alpha frequency bands. Cortical rsEEG source topography was estimated using eLORETA freeware. In the Healthy group, Edu+ participants exhibited significantly greater widespread rsEEG alpha source activities compared to Edu- participants, possibly reflecting neuroprotective neurophysiological mechanisms. Conversely, in the PDD group, Edu+ patients showed lower widespread rsEEG alpha source activities than Edu- patients, possibly indicating compensatory mechanisms. No significant differences in rsEEG source activities were observed between DLB-Edu+ and DLB-Edu- patients. Educational attainment may be associated with compensatory mechanisms that counteract the abnormal neurophysiological processes underlying rsEEG alpha rhythms and vigilance regulation in PDD patients, but not in DLB patients. Future studies combining rsEEG and neuroimaging techniques should investigate the metabolic and functional connectivity correlates of these putative compensatory mechanisms in the PDD brain. Early education may be a key investment for national governments, especially in low-income countries, to prevent the cognitive deficits of Parkinson’s disease along aging, thereby reducing the unbearable social and economic burden.
Author(s): Lopez S, Del Percio C, Lizio R, Noce G, Jakhar D, Soricelli A, Salvatore M, Guntekin B, Yener G, Massa F, Arnaldi D, Fama F, Pardini M, Ferri R, Carducci F, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor J-P, Hanoglu L, Yilmaz NH, Kiyi I, Ozbek-Isbitiren Y, D'Anselmo A, Bonanni L, Biundo R, D'Antonio F, Bruno G, Antonini A, Giubilei F, Cuoco S, Barone P, Frisoni GB, Rotondo R, De Pandis F, Babiloni C
Publication type: Article
Publication status: Published
Journal: GeroScience
Year: 2025
Pages: Epub ahead of print
Online publication date: 11/06/2025
Acceptance date: 07/05/2025
Date deposited: 24/07/2025
ISSN (print): 2509-2715
ISSN (electronic): 2509-2723
Publisher: Springer Science and Business Media Deutschland GmbH
URL: https://doi.org/10.1007/s11357-025-01703-9
DOI: 10.1007/s11357-025-01703-9
Data Access Statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Altmetrics provided by Altmetric
