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Lookup NU author(s): Dr Aragorn JonesORCiD, Dr Steven LisgoORCiD
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© 2025 Wiley-VCH GmbH. During development, precursor cells are continuously and intimately interacting with their extracellular environment, which guides their ability to generate functional tissues and organs. Much is known about the development of the neocortex in mammals. This information has largely been derived from histological analyses, heterochronic cell transplants, and genetic manipulations in mice, and to a lesser extent from transcriptomic and histological analyses in humans. However, these approaches have not led to a characterization of the extracellular composition of the developing neocortex in any species. Here, using a combination of single-cell transcriptomic analyses from published datasets and our proteomics and immunohistofluorescence analyses, we provide a more comprehensive and unbiased picture of the early developing fetal neocortex in humans and non-human primates. Our findings provide a starting point for further hypothesis-driven studies on structural and signaling components in the developing cortex that had previously not been identified.
Author(s): Vilicich F, Vettiatil D, Kattapong-Graber S, Nawsheen N, Patel N, Quezada A, Gurney E, Smith E, Nelson HN, Pesci S, Atrio J, Moreno N, Jones A, Murphy M, Benfield N, Hennebold J, Solanky N, Lisgo S, Glass I, Sidoli S
Publication type: Article
Publication status: Published
Journal: Proteomics
Year: 2025
Volume: 25
Issue: 13
Print publication date: 01/07/2025
Online publication date: 09/06/2025
Acceptance date: 17/04/2025
ISSN (print): 1615-9853
ISSN (electronic): 1615-9861
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/pmic.202400385
DOI: 10.1002/pmic.202400385
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