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Lookup NU author(s): Dr Kirstie Anderson, Dr Michael Keogh, Luca Gosse
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
© 2025 Anderson et al.Sleep disturbance in Parkinson’s disease (PD) is recognized to be one of the most common non-motor complications. It occurs before disease onset as a prodromal symptom, during and then throughout the disease course. Causes are multifactorial and can be multiple in the same patient. Specific sleep disorders that are known to occur in those with Parkinson’s disease include REM sleep behavior disorder, sleep disordered breathing including obstructive sleep apnea, restless legs and periodic limb movements, nightmare disorder, insomnia alongside direct side-effects of the medication used for therapy. One key question is whether these sleep disorders impact upon the motor and non-motor symptoms of Parkinson’s disease. There has been significant interest in recent years in using certain sleep disorders, in particular, REM sleep behavior disorder, as a biomarker both for those at risk of Parkinson’s disease but also influencing the subsequent severity and speed of progression. However, other sleep disorders in the general population may also increase the risk of developing Parkinson’s disease. It is important to understand whether the treatment of sleep disturbance and specific sleep disorders modifies the long-term risk of developing Parkinson’s disease or its progression.
Author(s): Anderson KN, Keogh MJ, Gosse L
Publication type: Review
Publication status: Published
Journal: Nature and Science of Sleep
Year: 2025
Volume: 17
Pages: 1521-1537
Online publication date: 28/06/2025
Acceptance date: 23/05/2025
ISSN (electronic): 1179-1608
Publisher: Dove Medical Press Ltd
URL: https://doi.org/10.2147/NSS.S478860
DOI: 10.2147/NSS.S478860
Data Access Statement: No new data was generated in this paper
