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Lookup NU author(s): Dr Niraj PrasadORCiD
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This study attempts to understand the phenomenon of sustained drug release from a moving carrier inside a microchannel numerically in contrast to the existing methods of in vitro experiments for net drug release measurements. This computational study will help understand drug release inside the constriction that is difficult to capture in experimental studies. The carrier was assumed as a finitely extensible non-linear elastic-Peterlin drop inside a Newtonian matrix. The carrier gets deformed while passing through the constricted channel resulting in a change in its surface area to volume ratio ultimately affecting the drug release. The net drug release is measured using the percentage drug release, and the drug distribution inside the channel is measured in terms of mixing efficiency. The influence of capillary number, viscosity ratio, carrier size, solvent viscosity ratio, and confinement ratio which shows their effect on carrier deformation is also investigated. These factors' optimal values were also found for better drug release that can prove to be useful for the drug synthesis. These simulations based on two-phase flows were performed on the open-source solver Basilisk.
Author(s): Srikara VS, Prasad NK, Dalal A
Publication type: Article
Publication status: Published
Journal: Physics of Fluids
Year: 2025
Volume: 37
Issue: 7
Print publication date: 01/07/2025
Online publication date: 22/07/2025
Acceptance date: 03/06/2025
ISSN (print): 1070-6631
ISSN (electronic): 1089-7666
Publisher: AIP Publishing
URL: https://doi.org/10.1063/5.0276831
DOI: 10.1063/5.0276831
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