ePrints

ECM formation and degradation during fibrosis, repair, and regeneration

Lookup NU author(s): Professor Quentin AnsteeORCiD

Downloads

• Published version [.pdf]

Licence

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

© The Author(s) 2025.Imperfect attempts at organ repair after repeated injury result in aberrant formation of extracellular matrix (ECM) and loss of tissue structure. This abnormal ECM goes from being a consequence of cellular dysregulation to become the backbone of a persistently fibrotic cell niche that compromises organic function and ultimately drives systemic disease. Here, we review our current understanding of the structure of the ECM, the mechanisms behind organ-specific fibrosis, resolution, healing and regeneration, as well as the development of anti-fibrotic strategies. We also discuss the design of biomarkers to investigate fibrosis pathophysiology, track fibrosis progression, systemic damage, and fibrosis resolution.

Publication metadata

Author(s): Mayorca-Guiliani AE, Leeming DJ, Henriksen K, Mortensen JH, Nielsen SH, Anstee QM, Sanyal AJ, Karsdal MA, Schuppan D

Publication type: Review

Publication status: Published

Journal: NPJ Metabolic Health and Disease

Year: 2025

Volume: 3

Issue: 1

Online publication date: 10/06/2025

Acceptance date: 15/04/2025

ISSN (electronic): 2948-2828

Publisher: Springer Nature

URL: https://doi.org/10.1038/s44324-025-00063-4

DOI: 10.1038/s44324-025-00063-4

Data Access Statement: No datasets were generated or analyzed during the current study

Share