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Modulation of metabolic, inflammatory, and fibrotic pathways by Semaglutide in MASLD

Lookup NU author(s): Professor Quentin AnsteeORCiD

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Author(s): Jara M, Norlin J, Skalshøi Kjær M, Almholt K, Bendtsen KM, Bugianesi E, Cusi K, Galsgaard ED, Geybels M, Gluud LL, Harder LM, Loomba R, Mazzoni G, Newsome PN, Nitze LN, Palle MS, Ratziu V, Sejling A, Wong V, Anstee QM, Knudsen LB

Publication type: Article

Publication status: Published

Journal: Nature Medicine

Year: 2025

Pages: Epub ahead of print

Online publication date: 21/07/2025

Acceptance date: 27/05/2025

Date deposited: 01/08/2025

ISSN (print): 1078-8956

ISSN (electronic): 1546-170X

Publisher: Nature Publishing Group

URL: https://doi.org/10.1038/s41591-025-03799-0

DOI: 10.1038/s41591-025-03799-0

Data Access Statement: Access request proposals can be found at https://www.novonordisk-trials.com/. Data must not be used for commercial purposes. RNA sequencing data obtained from the DIO-MASH and CDA-HFD animal studies will be publicly available in the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/) under their respective data repository accession numbers: GSE294629 and GSE294630. Details regarding the hallmark gene set collection are provided in ref. 12. Data are available at https://www.gsea-msigdb.org/gsea/msigdb/. Source data are provided with this paper. Code for preprocessing SomaScan proteomics data, performing statistical analyses and generating figures is available via Zenodo at https://doi.org/10.5281/zenodo.13356055 (ref. 44). R v.4.3.1 is available at https://cran.r-project.org/bin/windows/base/old/4.3.1/.

PubMed id: 40691365

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