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Developing biobanking processes for Alzheimer's disease and related dementia research in Africa: Experience from the Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP)

Lookup NU author(s): Dr Stella Paddick, Professor Richard Walker, Professor Raj KalariaORCiD, Dr Rufus Akinyemi

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Abstract

© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.The Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP) aims to recruit 5000 African participants (Alzheimer's disease [AD] and cognitively unimpaired controls) to generate genomic and biomarker data to better characterize AD neurobiology in Africa from countries that constitute the African Dementia Consortium (AfDC). Blood samples from study participants are separated into fractions and transported to the African Coordinating Centre (ACC: Ibadan, Nigeria), where DNA extraction and long-term biospecimen storage are carried out. Plasma and DNA aliquots are shipped to the John P. Hussman Institute for Human Genomics, University of Miami (HIHG-UM, Miami, USA) for genotyping, whole genome sequencing, and biomarker analysis. Innovative solutions were devised to mitigate challenges encountered so far. Our biobanking experience in a low-resource setting demonstrates the feasibility of establishing a successful African biobanking network, as an important infrastructure to support Alzheimer's disease and related dementias research in Africa. Highlights: Biobanking is gaining grounds in Africa in studies related to neurological disorders. The Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP) biobanking network is a new initiative to enhance infrastructure for Alzheimer's disease and related dementias (ADRD) research in Africa through the African Dementia Consortium. The processes of the stepwise creation and development of the READD-ADSP biobanking network have been guided by global best practices and regulatory standards. Challenges were encountered in the process of establishing the READD-ADSP biobank, and home-grown solutions were developed to mitigate the challenges. The READD-ADSP biobanking experience offers lessons to researchers in low-resource settings on how collaborative efforts between the global north and global south enhance cutting-edge team science to tackle ageing-associated brain disorders in low- and middle-income countries.

Publication metadata

Author(s): Akinwande KS, Whitehead P, Diala S, Coker M, Adams LD, Ogunronbi M, Balogun O, Boateng R, Kudzi W, Falayi A, Nyamai PK, Novela CF, Kelemu T, Abdulraheem JY, Adeleye O, Anyanwu RA, Ankamah J, Emmanuel BO, Imoh LC, Doku-Agama WA, Kumburu H, Kamulegeya R, Ige KB, Famuyiwa OO, Ogunde G, Ejimkonye FC, Akinyemi J, Cuccaro M, Mena P, Ogbole G, Elugbadebo O, Farombi T, Nichols M, Adeniyi S, Uthman M, Musyimi C, Mutiso V, Wahab K, Osaigbovo G, Nwazor E, Osemwegie N, Nwani P, Ogundele AT, Olowoyo P, Iwuozo EU, Mlaki DA, Obiako R, Sarfo F, Akpalu A, Adoukonou T, Ayele BA, Zenebe Y, Lwere K, Damasceno A, Njamnshi AK, Boshe J, Paddick S-M, Seshadri S, McCauley J, Walker R, Arulogun O, Okubadejo N, Baiyewu O, Byrd G, Owolabi M, Ndetei D, Kunkle BW, Griswold AJ, Kalaria RN, Vance J, Ogunniyi A, Pericak-Vance M, Akinyemi R

Publication type: Article

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2025

Volume: 21

Issue: 8

Print publication date: 01/08/2025

Online publication date: 17/08/2025

Acceptance date: 14/06/2025

Date deposited: 02/09/2025

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/alz.70559

DOI: 10.1002/alz.70559

PubMed id: 40819212

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