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Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP): A global effort to identify genetic factors in Alzheimer's disease

Lookup NU author(s): Dr Stella Paddick, Professor Raj KalariaORCiD

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Abstract

© 2025 The Author(s). Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.INTRODUCTION: Alzheimer's disease (AD) remains a major neurocognitive disorder of global health significance. Globalizing ancestral diversity in AD genetics is essential to identify causal variants, improve diagnosis, and enable equitable therapeutic interventions across populations. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) initiative addresses this by including African ancestry and Hispanic/Latinx (HL) ancestry populations. METHODS: READD-ADSP, a case–control study, aims to recruit, evaluate, and retain 13,000 participants: 5000 Indigenous Africans, 4000 African Americans, and 4000 Hispanic/Latinix individuals. In Africa, recruitment involves nine sub-Saharan African countries under the African Dementia Consortium, and with protocols ensuring standardized data collection, phenotype harmonization, culturally informed diagnostic algorithms, and robust community engagement. RESULTS: Study pparticipants are recruited, ascertained and retained. Blood samples and fractions (DNA, plasma, RNA) are biobanked for genomic, epigenomic, proteomic, and transcriptomic analyses. DISCUSSION: This study will advance precision ADRD medicine and establish a model for working with diverse global cohorts of brain disorders. Highlights: Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP) addresses critical gaps in Alzheimer's Disease and Related Dementias (ADRD) research by including underrepresented groups. The study recruits 13,000 participants of African, African American, and Hispanic/Latinx ancestries. Standardized protocols enable rigorous phenotyping and harmonization across diverse populations. Findings will inform precision medicine and reduce health disparities in ADRD outcomes.

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Author(s): Akinyemi R, Omotoso O, Kamada L, Ndetei D, Cuccaro M, Akpalu A, Adams LD, Sarfo SF, Njamnshi AK, Whitehead P, Okubadejo N, Ramon MP, Damasceno A, Williams S, Ayele B, Zenebe Y, Adokounou T, Ikanga J, Boshe J, Akinyemi J, Elugbadebo O, Obiako R, Wahab K, Iwuozo E, Akinwande K, Paddick S-M, Ogunronbi M, Musyimi C, Ibuchim A, Ogunde G, Coker M, Adeniji O, Cadmus E, Olalusi O, Ciesielski T, Nwani P, Blanton SH, Olowoyo P, Ojo O, Durodoye R, Osaigbovo G, Nakasujja N, Andrea MD, Ojagbemi A, Ogbole G, Farombi T, Ogundele AT, Seixas A, Adebusoye L, Nichols M, Nwazor EO, Osemwegie N, Guerchet M, Rajabli F, Olowookere O, McCauley JL, Arulogun O, Seshadri S, Owolabi M, Tosto G, Byrd G, Walker R, Reitz C, Bush W, Baiyewu O, Griswold AJ, Kunkle BW, Haines J, Kalaria RN, Vance JM, Ogunniyi A, Pericak-Vance M

Publication type: Article

Publication status: Published

Journal: Alzheimer's and Dementia: Translational Research and Clinical Interventions

Year: 2025

Volume: 11

Issue: 3

Print publication date: 01/09/2025

Online publication date: 25/08/2025

Acceptance date: 17/07/2025

Date deposited: 03/09/2025

ISSN (electronic): 2352-8737

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/trc2.70148

DOI: 10.1002/trc2.70148

Data Access Statement: Not applicable

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