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Lookup NU author(s): Dr Rachel Lee, Bassam Aljohani, Dr Jake McClementsORCiD, Dr Marloes Peeters, Professor Mark GeogheganORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Hyaluronic acid was crosslinked using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide to form hydrogels with low elastic modulus. These hydrogels were swollen in water and the elastic modulus was obtained with a contact mechanics approach in ambient conditions using a low-load mechanical tester under compression. The modulus was measured during both the approach and retraction of the cylindrical probe into the gel and was found to be of the order of 30 kPa. The modulus was also measured from a stress-strain curve (47 kPa), in reasonable agreement with the contact mechanics approach. However, nanoindentation and rheology measurements reveal much smaller moduli, indicating that the technique used interrogates different length scales within the gel. This has profound implications for the applications of hydrogels used, for example, in tissue engineering. The values reported here are likely to be appropriate for applications where contact with the spinal cord is necessary. It is argued that a contact mechanics approach is appropriate for the characterization of hydrogels for applications designed for contact with tissue
Author(s): Lee R, Hall EK, Aljohani BA, McClements J, Peeters M, Geoghegan M
Publication type: Article
Publication status: Published
Journal: Journal of Materials Science: Materials in Medicine
Year: 2025
Volume: 36
Issue: 1
Online publication date: 14/07/2025
Acceptance date: 19/03/2025
Date deposited: 09/09/2025
ISSN (electronic): 1573-4838
Publisher: Springer Nature
URL: https://doi.org/10.1007/s10856-025-06878-3
DOI: 10.1007/s10856-025-06878-3
Data Access Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
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