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Lookup NU author(s): Angus Reid, Dr ISABEL BURRIDGE, Loraine Kalra, Rob Thomas, Joe O'Donoghue, Dr Guy TaylorORCiD, Henry Cain
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2025 The AuthorsBackground: Partial breast reconstruction (PBR) using chest wall perforator flaps (CWPFs) is an oncoplastic technique utilised to facilitate breast conservation surgery (BCS). It is particularly applicable in women with a larger tumour-to-breast volume ratio requiring volume replacement rather than volume displacement. This single-centre retrospective cohort study aimed to explore the safety and efficacy of PBR using CWPFs. Method: All patients who underwent PBR using a CWPF following wide local excision between March 2016 and August 2024 were reviewed. Data was extracted from hospital electronic patient records and statistical analysis performed using R-Studio® (alpha = 0.05). Results: Of 290 cases identified: 237 had invasive cancers and 53 ductal carcinoma in situ (DCIS). The median age at presentation was 59 years and the median tumour size 22 mm, with multifocal tumours in 22.1 % of cases and extensive DCIS in 27.0 % of invasive cancers. Overall, complication rates were low (n = 83, 28.6 %) with 6.9 % of patients requiring a return to theatre. Margins were involved in 17.8 %, with 15.6 % requiring re-excision. The locoregional recurrence (LRR) rate was 2.9 % and disease-free survival (DFS) 93.8 % with a median follow-up of 3.1 years (n = 276). A subset analysis of women receiving surgery before January 2020 (n = 96) with a follow-up of 5.1 years had a LRR of 4.2 %. Conclusion: This study reports acceptable rates of complications, margin re-excision and LRR, demonstrating the safety and efficacy of utilising PBR with CWPFs for the treatment of breast cancer. CWPFs offer the opportunity to extend the boundaries of BCS to those women who may otherwise require a mastectomy.
Author(s): Reid A, Sibbering L, Burridge I, Kalra L, Critchley A, Thomas R, Pieri A, Carter J, O'Donoghue JM, Taylor G, Fairhurst K, Cain H
Publication type: Article
Publication status: Published
Journal: European Journal of Surgical Oncology
Year: 2025
Volume: 51
Issue: 11
Print publication date: 01/11/2025
Online publication date: 02/09/2025
Acceptance date: 02/09/2025
Date deposited: 30/09/2025
ISSN (print): 0748-7983
ISSN (electronic): 1532-2157
Publisher: W.B. Saunders Ltd
URL: https://doi.org/10.1016/j.ejso.2025.110430
DOI: 10.1016/j.ejso.2025.110430
Data Access Statement: The dataset was accessed through the Newcastle Upon Tyne Hospitals Trust electronic patient records. This is not publicly available at present as not all patients have consented for data to be shared and it contains confidential information such as patient identifiers.
PubMed id: 40939446
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