Browse by author
Lookup NU author(s): Professor Sophie HambletonORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025. Published by Oxford University Press on behalf of the British Society for Immunology. Since its discovery in the late 18th century, the role of vaccination in preventing death and disease has expanded across many infectious diseases and cancer. Key to our understanding of vaccine immunogenicity and efficacy is knowledge of the immune system itself. Inborn errors of immunity (IEI) represent a heterogeneous group of disorders characterized by impaired function of the immune system. Patients with IEI can have variable responses to vaccinations, depending on the nature and extent of the defect. Studies performed during the recent COVID-19 pandemic have brought unique insight into vaccine immunogenicity in individuals with IEI, knowledge that can be extended to the growing number of patients with secondary immunodeficiency arising from malignancy, organ transplantation, autoimmune conditions, and their treatments. In this review, we describe vaccine immunogenicity in IEI alongside their equivalent secondary immunodeficiencies and discuss what lessons can be learned about immunization strategies more broadly.
Author(s): Peters NE, Shields AM, Hambleton S, Richter AG
Publication type: Review
Publication status: Published
Journal: Clinical and Experimental Immunology
Year: 2025
Volume: 219
Issue: 1
Online publication date: 02/09/2025
Acceptance date: 24/07/2025
ISSN (print): 0009-9104
ISSN (electronic): 1365-2249
Publisher: Oxford University Press
URL: https://doi.org/10.1093/cei/uxaf059
DOI: 10.1093/cei/uxaf059
PubMed id: 40916471
Data Access Statement: The source material in this review was obtained from publicly available peer-reviewed literature, accessible through databases such as PubMed, Web of Science, and Scopus. No original data were generated for this review; therefore, all data supporting the findings are readily available within the cited publications.
