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Lookup NU author(s): Natalie Maffitt, Dr Supriyo Choudhury, Professor Rishi Kumar, Dr Demetris SoteropoulosORCiD, Dr Sasha KraskovORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 Crown. It is well established that patients with Parkinson's disease (PD) show deficits with movement execution, however experiences of motor planning dysfunction, and how they relate to the severity of motor symptoms, remains unclear. To investigate motor planning in PD, we designed a novel precision-grip task. PD patients showed significantly higher uncertainty in task performance compared to healthy controls, indicative of motor planning deficits. Performance of PD patients did not correlate with indicators of disease severity or subtype, yet patients on a higher daily levodopa dosage showed reduced motor planning deficits. Interestingly, these deficits were present even in recently diagnosed patients, implying that this measure may have potential as an early marker of motor planning impairment. These results suggest that the motor planning deficits revealed by our task may arise from separate pathological processes to that of motor execution dysfunction in PD, though might be alleviated with higher treatment dosages.
Author(s): Maffitt NJ, Banerjee S, Sarkar S, Majumdar S, Choudhury S, Kumar H, Soteropoulos DS, Kraskov A
Publication type: Article
Publication status: Published
Journal: Scientific Reports
Year: 2025
Volume: 15
Online publication date: 25/09/2025
Acceptance date: 28/08/2025
Date deposited: 06/10/2025
ISSN (electronic): 2045-2322
Publisher: Springer Nature
URL: https://doi.org/10.1038/s41598-025-18025-7
DOI: 10.1038/s41598-025-18025-7
Data Access Statement: All data generated or analysed during this study are included this article’s supplementary information files.
PubMed id: 40999021
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