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Dementia with Lewy bodies: A practical guide to clinical diagnosis and management

Lookup NU author(s): Dr Judith HarrisonORCiD, Dr Kirstie Anderson, Professor John-Paul TaylorORCiD

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Abstract

© Author(s) (or their employer(s)) 2025.Dementia with Lewy bodies (DLB) is a leading cause of late-life dementia which remains underdiagnosed and misdiagnosed, and is associated with significant diagnostic delay compared with non-DLB dementias. There is a pressing need for timely and accurate diagnosis of neurodegenerative disease with the emergence of pathologically targeted disease-modifying therapies. This review aims to provide neurologists with practical advice on the recognition of classical, prodromal and variant forms of DLB. We discuss the appropriate use of diagnostic modalities, along with advice on focused and practical management in the clinical setting.

Publication metadata

Author(s): Fullam S, Harrison JR, Anderson KN, Fearon C, O'Connor A, Taylor J-P, O'Dowd S

Publication type: Review

Publication status: Published

Journal: Practical Neurology

Year: 2025

Pages: epub ahead of print

Online publication date: 05/10/2025

Acceptance date: 19/08/2025

ISSN (print): 1474-7758

ISSN (electronic): 1474-7766

Publisher: BMJ Publishing Group

URL: https://doi.org/10.1136/pn-2025-004745

DOI: 10.1136/pn-2025-004745

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