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Lookup NU author(s): Dr Raheel Ahmed
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Background: Infective endocarditis (IE) is a rare but serious disease, often complicated by renal failure (RF). Staphylococcus aureus remains the main etiologic organism. The objective of this research is to investigate national trends in deaths attributable to comorbid IE and RF during 1999-2023, with emphasis on demographic and geographic variation. Methods: We utilized the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database. Multiple Cause-of-Death database was searched using ICD-10 codes to get mortality data. Annual Percentage Change (APC) and Average Annual Percentage Change (AAPC) were calculated using Join Point software. Result: 58,567 IE and RF deaths occurred during the study period. Joinpoint regression analysis detected varied trends by race and sex. In women, mortality declined until 2015, then increased thereafter. Men also followed the same pattern, with a steep fall in APC (2002–2016) followed by a steep rise (2016–2023). Racial disparities were seen: Black population experienced a brief rise in APC (1999–2004), a steep fall (2004–2016), and then an increase. White individuals also experienced a long-term fall followed by a steep rise post-2016. Conclusion: Mortality rates declined until 2016 but increased significantly thereafter, particularly among men, older adults, and residents of the Midwest, West, and rural areas. These findings highlight the need for targeted public health interventions against disparities in IE and RF outcomes.
Author(s): Khan A, Asghar T, Khan A, Noor H, Ashfaq F, Alam U, Ali KM, Shahid MA, Sehar A, Ahmed R
Publication type: Article
Publication status: In Press
Journal: Clinical Cardiology
Year: 2025
Acceptance date: 08/10/2025
ISSN (print): 0160-9289
ISSN (electronic): 1932-8737
Publisher: John Wiley & Sons, Inc.
