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Lookup NU author(s): Professor Simon PearceORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2025. Published by Oxford University Press on behalf of European Society of Endocrinology.Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project—a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. Methods: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in adrenal endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. Results: For adrenal disorders, research priorities span primary and secondary adrenal insufficiency, adrenal tumours, and endocrine hypertension. Key areas include development of biomarkers and replacement therapies, improved understanding of disease mechanisms, diagnostic procedure optimization, and establishment of pan-European registries. Special emphasis is placed on personalized treatment approaches. Conclusions: The adrenal component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into adrenal disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of adrenal disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
Author(s): Husebye ES, Assie G, Krone N, Achermann JC, Altieri B, Amar L, Araujo-Castro M, Brown MJ, Casey RT, Claahsen-Van der Grinten HL, Davies E, Deinum J, Fluck CE, Kastelan D, Kroiss M, Mulatero P, Laakso S, Pearce SH, Reincke M, Reisch N, Robledo M, Ronchi CL, Vassiliadi DA, Wiegering V, Zennaro M-C
Publication type: Review
Publication status: Published
Journal: European Journal of Endocrinology
Year: 2025
Volume: 193
Issue: Supplement_2
Pages: ii12-ii22
Online publication date: 17/10/2025
Acceptance date: 09/05/2025
ISSN (print): 0804-4643
ISSN (electronic): 1479-683X
Publisher: Oxford University Press
URL: https://doi.org/10.1093/ejendo/lvaf063
DOI: 10.1093/ejendo/lvaf063
PubMed id: 41104475
