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Lookup NU author(s): Dr Ríona McArdle, Dr Marie PooleORCiD
This is the authors' accepted manuscript of an article published in its final definitive form in 2025. For re-use rights please refer to the publishers terms and conditions.
Background:Dementia is a global health priority. Early identification of dementia in asymptomatic or mildly symptomatic individuals (i.e. dementia risk detection) is proposed as a clinical solution for early intervention and could support researchers to identify novel neuropathological targets and recruit to clinical trials. Digital biomarkers of behavioral or physiological markers, such as sleep, are cited as a potential low-cost, non-invasive, and objective methods for dementia risk detection. Understanding perspectives on digital biomarkers, particularly acceptability, from potential end users and clinical staff is required when considering implementation within any clinical service. With emerging evidence of sleep as a risk marker for dementia, efficacy of the Dementia Research Institute – Sleep Index (DRI-SI), based on continuous remote monitoring of sleep patterns detected by a digital sleep mat, for dementia risk detection is currently being explored by the InSleep46 study.Objective:This qualitative sub-study aimed to explore perspectives of potential end users and primary care physicians regarding the use of a digital sleep mat to measure the DRI-SI and its application towards dementia risk detection.Methods:31 potential end users (age: 31-82 years, 11:20 female: males) from Newcastle and London, UK, with personal or caregiving experience related to dementia, took part in qualitative focus group workshops. They shared opinions on integrating the sleep mat into their homes, the DRI-SI’s potential for identifying dementia risk, and the necessary information for engagement with related clinical services. Seven primary care physicians from across England participated in semi-structured interviews regarding the potential application of the DRI-SI in dementia risk detection and its integration into current clinical practice. Inductive thematic analysis was conducted to identify key themes.Results:Four key themes emerged from end user focus groups: 1) Practical use, 2) Acceptability, 3) Clinical management, and 4) Data concerns. Three main themes came from the semi-structured interviews with physicians: 1) Acceptability, 2) Healthcare Provision, and 3) Practical considerations. Common themes were identified in both groups but held differing perspectives. End users were focused on practical aspects of integrating the digital sleep mat within their daily life, the effect of the DRI-SI on clinical care and privacy concerns regarding data use. Primary care physicians were concerned more broadly with how the DRI-SI and dementia risk detection service would integrate into current clinical practice, the impact on clinical resources and patient wellbeing, and need for clinical actionability and guidance on discussing results with patients.Conclusions:End users would find the DRI-SI acceptable as part of their clinical care, but primary care physicians require a more robust evidence base. Future research should explore integration of the DRI-SI into clinical care/research pathways to enhance clinical acceptability. Five key recommendations have been made for further development of digital biomarkers for dementia risk populations.
Author(s): Mc Ardle R, Poole M, Horrocks S, King-Robson J, Schott J, Sharp D, Harrison M, Robinson L
Publication type: Article
Publication status: In Press
Journal: JMIR Aging
Year: 2025
Acceptance date: 06/11/2025
Date deposited: 06/11/2025
URL: https://preprints.jmir.org/preprint/74307/accepted
DOI: 10.2196/74307
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