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Lookup NU author(s): Dr Shantanu Sengupta, Dr Nduka Okwose, Dr Guy MacGowanORCiD, Professor Djordje JakovljevicORCiD
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© 2025 Belgian Society of Cardiology. Background: There is limited evidence regarding the effect of physical activity interventions on exercise tolerance, left ventricular (LV) filling pressure, and quality of life (QoL) in patients with heart failure with preserved ejection fraction (HFpEF). This study assessed the acceptability, feasibility, and physiological outcome of a novel, personalised, home-based physical activity intervention in HFpEF. Methods: This was a prospective, feasibility randomised study. Forty HFpEF patients, clinically stable were randomised 2:1 ratio to an intervention group (60±6 years, n=25, 12 male) which involved increasing daily physical activity by 2000 steps from baseline (Active-at-Home-HF) or to standard care control group (60±7 years, n=15, four male) for 12 weeks. Before and after 12 weeks, patients underwent supervised exercise stress test on treadmill, and assessment of exercise stress echocardiography, QoL (Minnesota Living with Heart Failure questionnaire) and N-terminal prohormone of brain natriuretic peptide (NTproBNP) were also assessed before and after intervention. All patients were monitored weekly via telephone and pedometers. Results: In the intervention group, patients achieved target step count after three weeks (from 4457±653 to 6592±546 steps per day, p<0.001), and maintained throughout the duration of the study. Exercise duration increased significantly in intervention (350±122 vs 463±135 s) but not in control group (399±126 vs 358±88 s, p = 0.007 group × time interaction) at follow-up. Left ventricular filling pressure (E/E′) improved in intervention group (12.43±3.6 vs 9.72±1.86) but was not significantly different compared to controls (12.86±3.17 vs 12.44±2.23) (group × time interaction, p=0.08). The left atrial (LA) reservoir strain significantly improved in intervention group (25.5±4.4 vs 23.3±4.5%) and not in non-intervention group (21.8±4.4 vs 21.9±4.8%) (p=0.015). There was no change in NTproBNP, LV ejection fraction, LV longitudinal strain, stroke volume, cardiac output, cardiac power output and right ventricular systolic function in the intervention or control group (p>0.05). There were no adverse events. Conclusions: In this study of HFpEF patients, a 12-week personalised home-based physical activity intervention is feasible, acceptable, safe, improves LA function, exercise duration and QoL and may improve LV filling pressures.
Author(s): Sengupta SP, Okwose NC, MacGowan GA, Jakovljevic DG
Publication type: Article
Publication status: Published
Journal: Acta Cardiologica
Year: 2025
Pages: Epub ahead of print
Online publication date: 04/11/2025
Acceptance date: 09/10/2025
ISSN (print): 0001-5385
ISSN (electronic): 0373-7934
Publisher: Taylor and Francis Ltd
URL: https://doi.org/10.1080/00015385.2025.2576440
DOI: 10.1080/00015385.2025.2576440
PubMed id: 41185607
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