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Lookup NU author(s): Dr Alex ThompsonORCiD, Professor Nick ReynoldsORCiD, Professor Barbara HanrattyORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Author(s). Health Expectations published by John Wiley & Sons Ltd.Background: Public and patient involvement and engagement (PPIE) is intended to shape research priorities and improve relevance and impact. However, implementing PPIE in complex fields such as artificial intelligence (AI) and big data health research presents specific challenges. This study explores the issues and barriers to meaningful PPIE using the AI-Multiply project as a case example. Methods: AI-Multiply is a large, interdisciplinary UK-based research project using AI and routine health data to investigate trajectories of multiple long-term conditions and polypharmacy. PPIE was embedded across all five work packages. We used a mixed-methods approach, drawing on CUBE framework surveys, PPIE feedback forms and impact logs to evaluate involvement. Data were analysed thematically using a ‘follow-a-thread’ approach to identify key issues across sources. Results: Three themes were identified: (1) differing priorities—public contributors prioritised person-centred outcomes, while researchers focused on data-driven healthcare metrics, often constrained by data availability; (2) movement on both sides—both researchers and contributors expressed early apprehension, but mutual trust and integration developed over time; and (3) the importance of established guidance—many issues raised echoed longstanding PPIE guidance on clarity, feedback and facilitation. Conclusion: While AI and data-specific challenges exist, many PPIE issues in this context relate to applying existing good practice in complex projects. Strong PPIE leadership, early expectation-setting and consistent facilitation are critical for success. Findings will inform the development of practical tools to support involvement in data-driven research. Patient or Public Contribution: Public contributors with lived experience of multiple long-term conditions contributed to the interpretation of data and co-authored this manuscript.
Author(s): Thompson A, Bartle V, Remfry EA, Reynolds DJ, Barnes MR, Reynolds NJ, Hanratty B
Publication type: Article
Publication status: Published
Journal: Health Expectations
Year: 2025
Volume: 28
Issue: 6
Online publication date: 14/11/2025
Acceptance date: 09/09/2025
Date deposited: 27/11/2025
ISSN (print): 1369-6513
ISSN (electronic): 1369-7625
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/hex.70490
DOI: 10.1111/hex.70490
Data Access Statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions
PubMed id: 41235438
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