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Lookup NU author(s): Cyril Onwuelazu UtehORCiD
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Aims: To investigate the clinical trial landscape for multiple sclerosis over the last year. Multiple sclerosis is a chronic neurological and autoimmune disorder. It can affect people of all ages. However, young adults and females are disproportionately affected. Globally, North America and Europe are the top two regions with the highest burden of multiple sclerosis. Methods: A search of clinical trials (CT) on multiple sclerosis was conducted on the ClinicalTrials.gov database from September - November 2025, to identify CTs first posted between the 1st of November 2024 and the 17th of November 2025 (date of last search). The search outputs were screened based on developed inclusion and exclusion criteria. See Table 1 below for the inclusion/exclusion criteria. Data analysis was conducted using Power BI Desktop Version: 2.149.911.0 64-bit (November 2025). Results: A total of 4,382 CTs identified from the search were screened using the inclusion and exclusion criteria. Following screening, 82 CTs on multiple sclerosis with an estimated 8596 participants were included in the analysis. The majority of the CTs were either recruiting, 49% (40/82) or not yet recruiting, 41% (34/82). Approximately 76% (62/82) of CTs were either at the Phase 1 or Phase 2 stage. Almost all the CTs, 96% (79/82), included adult or older adult participants. The most common intervention types for multiple sclerosis were drugs, at 61% (50/82), and biologicals, at 33% (27/82). More than half of the CTs (63%) were industry sponsored. Conclusions: The age distribution of the participants in the CT landscape typically reflected the age most at risk of multiple sclerosis (adults and older adults). The different identified intervention types also reflected the complex nature of care needed for multiple sclerosis. This study was limited to CTs posted on ClinicalTrials.gov.
Author(s): Uteh CO
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: The International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD26)
Year of Conference: 2026
Pages: 63-65
Online publication date: 09/12/2025
Acceptance date: 01/12/2025
Date deposited: 16/12/2025
URL: https://cslide.ctimeetingtech.com/global_storage/media/content/adpd26/ADPD26_-_on-demand_orals_for_website_DEC_9.pdf
