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Lookup NU author(s): Cyril Onwuelazu UtehORCiD
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Aims: Huntington’s disease is a complex and chronic neurological, mental and physical disability. Presently, no definitive cure for the disease exists, and available treatments focus on managing symptoms and improving quality of life. A comprehensive and multidisciplinary care is recommended for the management of Huntington’s disease. This study, therefore, investigated the diverse emerging interventions aimed at managing Huntington’s disease within the last 10 years. Methods: An analysis of the clinical trial (CT) landscape for Huntington’s disease on the ClinicalTrials.gov registry was first carried out on June 4th, 2025, and again after three months on September 3rd, 2025. Ongoing and completed CTs whose start date falls within the last ten years (September 1st, 2015, to September 3rd, 2025) were analysed to investigate their status, phases, types and geographical spread of interventions. See the inclusion and exclusion criteria for other details. Results: A total of 44 CTs on Huntington’s disease, comprising 4656 enrolled participants, were included in the analysis. The interventions included drugs, gene therapies, stem cell therapies, radiation, exercise and dietary supplements. Notably, the top two interventions were drugs: 32/44 (73%) CTs and gene therapies: 4/44 (9%). In terms of CT Phase, the majority of the CTs, 34/44 (77%), were either phases 1 or 2. The top two CTs' Status showed 26/44 (59%) completed, and 9/44 (20%) recruiting. The geographical spread of the CTs showed 14/44 (32%) in North America only, and 11/44(25%) in Europe only. Other regions included Asia, Oceania and South America, but none from Africa. Conclusions: The diverse intervention types from the CTs highlight the complex nature of care for Huntington’s disease. Finally, this study was limited to CTs published on the ClinicaTrials.gov, and does not generalise across all existing CT registers.
Author(s): Uteh CO
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: The International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD26)
Year of Conference: 2026
Pages: 23-26
Online publication date: 09/12/2025
Acceptance date: 21/10/2025
Date deposited: 16/12/2025
URL: https://cslide.ctimeetingtech.com/global_storage/media/content/adpd26/ADPD26_-_eposters_for_website_DEC_9.pdf
