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Lookup NU author(s): Csaba Kozma, Dr Jonathan Horsley, Dr Gerard HallORCiD, Callum Simpson, Professor Peter TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Author(s). Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. Objective: Precise localization of epileptogenic tissue is critical for successful surgery in drug-resistant temporal lobe epilepsy (TLE) but is challenging in those requiring intracranial electroencephalography (iEEG). A range of modalities are used for localization, including magnetic resonance imaging (MRI) and EEG, which are typically integrated qualitatively by the clinical team. Methods: This study quantitatively performed retrospective analysis of three modalities in 40 individuals with TLE who underwent subsequent resective surgery: preoperative diffusion-weighted MRI, T1-weighted MRI, and iEEG. Brain abnormalities in gray matter (GM) volume, superficial white matter (SWM) mean diffusivity, and interictal iEEG band power were derived by comparison to 97 MRI controls and 247 subjects with iEEG. We hypothesized that combined abnormalities in GM and SWM could differentiate postsurgical outcomes and adding iEEG abnormalities would improve outcome differentiation. Results: MRI (union of GM and SWM) abnormalities were primarily concentrated in the ipsilateral hippocampus and inferior temporal regions. Resection of these abnormal regions effectively differentiated seizure-free outcomes (area under the curve [AUC] =.76, area under the precision–recall curve [AUPRC] =.78, p <.01), corroborating previous results from larger TLE cohorts. Adding iEEG abnormalities improved outcome differentiation (AUC =.92, AUPRC =.89, p <.01; z = 2.01, p <.05). MRI abnormalities were more likely to colocalize with iEEG implantation sites (z = 6.26, p <.01) and iEEG abnormalities (z = 4.34, p <.01) in individuals with favorable outcomes (International League Against Epilepsy [ILAE] class 1 and 2), but not in those with less favorable outcomes (ILAE class 3+). Significance: Combining quantitative MRI-derived GM and SWM abnormalities with interictal iEEG data improves localization of epileptogenic tissue and postsurgical outcome differentiation. Multimodal approaches may offer added value for surgical planning in complex situations.
Author(s): Kozma C, Horsley J, Hall G, Simpson C, de Tisi J, Miserocchi A, Diehl B, McEvoy AW, Vos SB, Winston GP, Wang Y, Duncan JS, Taylor PN
Publication type: Article
Publication status: Published
Journal: Epilepsia
Year: 2025
Pages: Epub ahead of print
Online publication date: 22/12/2025
Acceptance date: 17/11/2025
Date deposited: 07/01/2026
ISSN (print): 0013-9580
ISSN (electronic): 1528-1167
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/epi.70042
DOI: 10.1111/epi.70042
Data Access Statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
PubMed id: 41427675
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