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Lookup NU author(s): Dr Scott McDonaldORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2025 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. BACKGROUND: Dual decline in gait and cognition is associated with an increased risk of dementia, with the strongest association seen between gait speed and delayed memory. However, the underlying brain correlates remain unknown. This study aimed to explore the associations between regional brain volumes and dual decline in gait speed and delayed memory. METHOD: Participants over 60 years were randomly selected from the Southern Tasmanian electoral roll (Australia). Baseline brain MRI and three serial gait speed and delayed memory assessments were performed on average 2.5 years apart. Participants were classified into four groups depending on tertiles of annual decline in gait speed and memory: non-decline, gait only, cognition only, and dual decline. Twenty-one regional brain volumes (in frontal, parietal, temporal, subcortical, brain stem and cerebellar areas) were preselected based on previous studies of gait and memory. Multinomial logistic regression was used to examine the associations between baseline regional brain volumes and the four groups. RESULT: The mean age of participants was 70.9 ± SD 6.7 years (n = 266). Lower volume in six brain regions (superior frontal gyrus, anterior cingulate cortex, middle frontal gyrus, thalamus, orbitofrontal cortex, hippocampus) were associated with a higher risk of dual decline. Lower volumes in the thalamus and cerebellum were associated with a higher risk of gait only and cognitive only decline respectively. However, these associations did not remain significant after correction for multiple comparisons. CONCLUSION: In this exploratory study regions related to memory, executive function, motor, and sensory motor integration were found to have associations with dual decline. Larger studies investigating a wider range of brain pathologies are required to fully understand the mechanisms underlying dual decline.
Author(s): Karunarathna S, Breslin M, Alty JE, McDonald JS, Beare R, Srikanth VK, Collyer TA, Callisaya ML
Publication type: Article
Publication status: Published
Journal: Alzheimer's & Dementia
Year: 2025
Volume: 21
Issue: S2
Online publication date: 24/12/2025
Acceptance date: 02/04/2018
Date deposited: 08/01/2026
ISSN (print): 1552-5260
ISSN (electronic): 1552-5279
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/alz70856_101761
DOI: 10.1002/alz70856_101761
PubMed id: 41445041
Notes: Supplement: Biomarkers
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