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Ensembl 2026

Lookup NU author(s): Lucas CortesORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© The Author(s) 2025. Published by Oxford University Press. The Ensembl project (https://www.ensembl.org) is a public and open resource providing access to genomes, annotations, high-quality tools, and methods applicable to species from across the tree of life. This year has witnessed nearly a doubling in our rate of annotation and genome release, with 1927 new genomes released, with the total number of genomes now standing at 37546. This includes expanded support for the human and barley pangenomes. We also present two new interfaces providing improved mechanisms to explore and interrogate genome regulation annotations. As our focus remains on sustainable scaling, we have archived Ensembl Rapid Release and accelerated the move to the new Ensembl platform. Ensembl release 116 (Q1-2026) will be the last release on the current platform.


Publication metadata

Author(s): Yates AD, Austine-Orimoloye O, Azov AG, Barba M, Barnes I, Barrera-Enriquez VP, Becker A, Bennett R, Berry A, Bhai J, Bhurji SK, Branco Lins PR, Brooks L, Budhanuru Ramaraju S, Campbell LI, Carbajo Martinez M, Carpenter J, Charkhchi M, Cortes LA, Davidson C, Dickson S, Dodiya K, Donaldson S, El Houdaigui B, El Naboulsi T, Fairbrother-Browne A, Falola O, Fatima R, Gonzalez Martinez J, Gurbich T, Hall H, Hardy M, Hollis Z, Hunt T, Kay M, Kaikala V, Lazar A, Lemos D, Lodha D, Mathlouthi N, Merino GA, Merritt R, Mirabueno LP, Mushtaq A, Nakib Hossain S, Perez-Silva JG, Pilizota I, Poppleton D, Prosovetskaia I, Raj S, Salam AIA, Saraf S, Sinha S, Sipos B, Sitnik V, Suner M-M, Surapaneni L, Tierney JAS, Urbina-Gomez D, Veidenberg A, Walsh TA, Allen JM, Alvarez-Jarreta J, Cheema J, Batista da Rocha J, De Silva NH, Tricomi FF, Giorgetti S, Ilsley GR, Keatley J, Loveland JE, Mudge JM, Naamati G, Tate J, Willhoft NL, Winterbottom A, Flint BR, Frankish A, Haggerty L, Hunt SE, Clark EL, Dyer SC, Freeberg MA, Martin FJ, Finn RD

Publication type: Article

Publication status: Published

Journal: Nucleic Acids Research

Year: 2026

Volume: 54

Issue: D1

Pages: D1053-D1060

Print publication date: 06/01/2026

Online publication date: 26/11/2025

Acceptance date: 16/10/2025

Date deposited: 03/02/2026

ISSN (print): 0305-1048

ISSN (electronic): 1362-4962

Publisher: Oxford University Press

URL: https://doi.org/10.1093/nar/gkaf1239

DOI: 10.1093/nar/gkaf1239

Data Access Statement: All Ensembl data is made available without restriction from our main website (https://www.ensembl.org), Ensembl Beta (https://beta.ensembl.org) and portals (https://plants.ensembl.org, https://metazoa.ensembl.org, https://fungi.ensembl.org, https://protists.ensembl.org, https://bacteria.ensembl.org, https://grch37.ensembl.org, https://covid-19.ensembl.org). Data is also available for bulk access via our FTP site (https://ftp.ensembl.org) and programmatically (https://rest.ensembl.org,https://beta.ensembl.org/data/graphql). Ensembl code is available from GitHub (https://github.com/Ensembl and https://github.com/EnsemblGenomes) under an open source Apache 2.0 licence. News about our releases and services can be found on our blog (https://www.ensembl.info), our announce mailing list (https://lists.ensembl.org/mailman/listinfo/announce), X (@ensembl; https://x.com/ensembl), LinkedIn (https://www.linkedin.com/company/ensemblgenomebrowser) and Facebook (https://facebook.com/Ensembl.org).

PubMed id: 41296548


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Funding

Funder referenceFunder name
ELIXIR
European Molecular Biology Laboratory
Gordon and Betty Moore Foundation, grant CBMF8897
iotechnology and Biological Sciences Research Council [BB/W019108/1, BB/P016855/1, BB/T015608/1, BB/T01461X/1]
National Human Genome Research Institute of the National Institutes of Health under award number 2U24HG007234-09, U41HG010972, R01 HG010485, U24HG011451, and 2U24HG007497-05
Open Targets
Wellcome Trust [212925/Z/18/Z, 226458/Z/22/Z, 226083/Z/22/Z]
Wellcome Trust [222155/Z/20/Z]
uropean Union’s Horizon 2020 research and innovation programme

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