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Lookup NU author(s): Dr Gerard HallORCiD, Professor Peter TaylorORCiD, Professor Yujiang WangORCiD
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© 2026 International League Against Epilepsy. Objective: Determining patient-specific thalamic connectivity alterations may be an important step toward personalized surgical and neuromodulation strategies, but no data are available to support this concept in pediatric cohorts. This study investigated thalamocortical structural connectivity profiles in children with focal-onset epilepsy of different seizure-onset zones. Methods: This neuroimaging, case–control study compared structural connectivity of four thalamic nuclei (anteroventral [AV], centromedian [CM], mediodorsal [MDPf], and pulvinar [PUL]) between 81 children who underwent surgery for focal-onset epilepsy (median age = 12.2 years) and 63 controls (median age = 12.8 years). Using preoperative 3-Tesla diffusion magnetic resonance imaging (dMRI), brain (Lausanne) and thalamic (THOMAS) parcellations combined with tractography generated structural connectomes based on streamline counts. Connectivity strength of each thalamic nucleus was calculated by summing the weights of each connecting brain region. Results: Patients had higher structural connectivity strengths than controls of the thalamic nuclei (effect size (η2ₚ) =.072; p =.015), differentially involving nucleus regions, but there was no overall difference in nucleus volumes (η2ₚ <.000; p =.968). When comparing patient groups defined by seizure-onset zones, it emerged that reduced AV connectivity strength was specific to the hippocampal sclerosis group, whereas CM, MDPf, and PUL connectivity was similarly high in all the patient groups, including those with frontal or temporal lobe epilepsy. Patients who were seizure-free after surgery had a lower ipsilateral and a higher contralateral connectivity strength (η2ₚ =.111; p =.005) and volumes (η2ₚ =.073; p =.025) of thalamic nuclei compared to those who were not. Significance: This study provides unique data suggesting that different pediatric focal epilepsies have distinct structural thalamocortical connectivity and volumetric profiles. The structural connectivity and volumetric asymmetries of the thalami have an association with postoperative seizure freedom. More studies are required to further understand the thalamic connectivity signatures that may have implications for precision surgical planning and neuromodulation targeting for focal-onset epilepsy.
Author(s): Piper RJ, Feng X, Chari A, Eriksson MH, Wagstyl K, Seunarine K, Hall G, Taylor PN, Wang Y, Clayden JD, Clark CA, Tahir MZ, Carmichael DW, Baldeweg T, Tisdall MM
Publication type: Article
Publication status: Published
Journal: Epilepsia
Year: 2026
Pages: Epub ahead of print
Online publication date: 19/01/2026
Acceptance date: 31/12/2025
ISSN (print): 0013-9580
ISSN (electronic): 1528-1167
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/epi.70099
DOI: 10.1002/epi.70099
PubMed id: 41553602
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