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The Synthesis of Tetrakis(N,N-dimethylaminomethyl)ferroceneand Its Bimetallic Nickel(II) Dichloride Complex: The Search forPrecursors for Methoxycarbonylation Ligands

Lookup NU author(s): Professor William Clegg

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Abstract

The family of N,N-dimethylaminomethylferrocene compounds is one of the most importantin ferrocene chemistry. They serve as precursors for a range of anti-malarial andanti-tumour medicinal compounds, in addition to being key precursors for ferrocene ligandsin the Lucite alpha process. A brief discussion on the importance and synthesisof N,N-dimethylaminomethyl-substituted ferrocenes preludes the synthesis of the newligand, 1,1′,2,2′-tetrakis-(N,N-dimethylaminomethyl)ferrocene. The crystal structure ofthis compound is reported, and a comparison is made with its disubstituted analogue,1,2-bis-(N,N-dimethylaminomethyl)ferrocene. The tetrahedral nickel dichloride complexesof both these ligands have been crystallographically characterised. Finally, a pointer tofuture research in the area is given, which includes a discussion of a new method to extractferrocenylmethylamines from mixtures using additives and a new synthetic avenue fromsubstituted cyclopentadiene itself.

Publication metadata

Author(s): Butler IR, Horton PN, Clegg W, Coles SJ, Murphy L, Elliott S

Publication type: Article

Publication status: Published

Journal: Inorganics

Year: 2026

Volume: 14

Issue: 2

Print publication date: 26/01/2026

Online publication date: 26/01/2026

Acceptance date: 12/01/2026

Date deposited: 03/02/2026

ISSN (electronic): 2304-6740

Publisher: MDPI

URL: https://doi.org/10.3390/inorganics14020037

DOI: 10.3390/inorganics14020037

Data Access Statement: The original contributions presented in this study are included in the article/Supplementary Materials. Further inquiries can be directed to the corresponding author

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