Browse by author
Lookup NU author(s): Dr Rufus Akinyemi
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© Springer Nature America, Inc. 2026.Globally, the burden of dementia profoundly affects low- and middle-income countries (LMICs), with a greater burden and risk for late-life women than men. Structural and social determinants of health, crucial constructs conferring risk and protection from later-life dementia, are relatively understudied, yet essential in LMICs. Typical neuroscience studies have historically been small, with highly selected samples that do not generalize well to target populations in LMICs. To better understand gender and sex differences in dementia risk in LMICs, this Perspective lays out a guiding framework for a global dementia research plan—the Population Neuroscience-Dementia Syndemics Framework. Population neuroscience considers the brain in a multilevel context, from a lifecourse perspective, using tools to enhance internal and external validity, while syndemics suggest that diseases and social conditions may cluster and interact in populations with syndemic risk factors—sociocultural, political, economic, and environmental factors that promote stress pathways and disease.
Author(s): Shaaban CE, Suryadevara V, Hill AV, Milani SA, Agarwal P, Aggarwal NT, Akinyemi RO, Alladi S, Brown MJ, Caldwell JZK, Caramelli P, DuBose L, Ellajosyula R, Esiaka DK, Gibson A, Griffith P, Harper J, Karanja W, Li W, Llibre-Guerra JJ, Loi SM, Mielke MM, Molina-Henry DP, Ogunniyi A, Pudumjee S, Stites SD, Sundermann E, Turner AD, Vila-Castelar C, Viswanathan J, Trani J-F, Babulal GM
Publication type: Article
Publication status: Published
Journal: Nature Aging
Year: 2026
Volume: 6
Issue: 1
Pages: 38-55
Online publication date: 21/01/2026
Acceptance date: 04/11/2025
ISSN (electronic): 2662-8465
Publisher: Springer
URL: https://doi.org/10.1038/s43587-025-01035-5
DOI: 10.1038/s43587-025-01035-5
Altmetrics provided by Altmetric
