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Lookup NU author(s): Roxane Hillier, Professor David SteelORCiD
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© 2025 American Academy of Ophthalmology.Purpose To evaluate long-term anatomical and visual outcomes after pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) flap in the treatment of optic disc pit maculopathy (ODPM). Design Multicenter, retrospective cohort study. Participants Patients with congenital ODPM who underwent primary or revisional PPV with ILM flap, with a minimum follow-up of 12 months. Methods Clinical data were retrospectively collected, including baseline characteristics, surgical details, fluid distribution, central macular thickness (CMT), and best-corrected visual acuity (BCVA) at baseline and at 1, 6, and 12 months postoperatively, as well as at the final follow-up. Main Outcomes Measures The primary outcome was the rate of anatomical resolution (defined as complete reabsorption of intraretinal fluid and subretinal fluid [SRF]) at 12 months. Secondary outcomes included anatomical resolution at last follow-up, change in CMT and BCVA, fluid distribution patterns, and identification of predictors of treatment response. Results A total of 71 eyes from 71 patients were included. Complete resolution was achieved in 33.8% of cases at 12 months, increasing to 57.7% at a median follow-up of 24 months. An additional 19.7% showed anatomical improvement. Mean CMT decreased significantly (from 639.5 μ m to 316.7 μ m at 12 months and 297.2 μ m at final follow-up, P < .0001 for both), and median BCVA improved from 0.6 (20/80) to 0.3 (20/40) logarithm of the minimum angle of resolution (LogMAR) at both 12-month and final follow-up ( P < .001). Anatomical and visual outcomes were comparable between primary and revisional surgeries. Multivariate analysis revealed that female sex (odds ratio [OR] = 5.7, P = .008) and presence of SRF only (OR = 8.0, P = .005) were independent predictors of complete resolution. Subretinal fluid-only configuration was also significantly associated with ≥0.2 LogMAR (2 Snellen lines) visual gain (OR = 5.0, P = .038). Intraoperative laser to optic disc edge was negatively associated with visual improvement (OR = 3.5, P = .048). Conclusions Pars plana vitrectomy with ILM flap offers favorable long-term anatomical and functional outcomes for ODPM, thus representing an effective treatment, in particular in revision cases. The presence of isolated SRF appears to be a positive prognostic marker for both anatomical and visual recovery. In contrast, adjunctive laser photocoagulation may negatively impact visual recovery. Our findings support caution against unnecessary early reoperation. Financial Disclosure(s) The authors have no proprietary or commercial interest in any materials discussed in this article.
Author(s): Ferrara M, Vaccaro S, Stanzel B, Hillier RJ, Figueroa M, Caporossi T, Pertile G, Romano MR, Rizzo S, Steel DHW, Attanasio M, Caporossi T, Caputo G, da Cruz L, De Angelis L, Ferrara M, Figueroa M, Fiore T, Gotzaridis S, Govetto A, Haynes R, Henderson RH, Hillier RJ, Hughes E, Hussain R, Jalil A, Kaprinis K, Laidlaw A, Lupidi M, Mariotti C, Mastropasqua R, Morescalchi F, Pertile G, Peschke P, Pearce I, Piergentili M, Priglinger S, Rizzo S, Romano MR, Rossi T, Sandinha T, Sabatino F, Sim PY, Stamenkovic M, Stanzel B, Steel D, Szurman P, Vallejo-Garcia J, Vaccaro S, Williamson T, Wolf A, Yorston D
Publication type: Article
Publication status: Published
Journal: Ophthalmology Retina
Year: 2026
Pages: epub ahead of print
Online publication date: 19/12/2025
Acceptance date: 15/12/2025
ISSN (print): 2468-7219
ISSN (electronic): 2468-6530
Publisher: Elsevier Inc.
URL: https://doi.org/10.1016/j.oret.2025.12.008
DOI: 10.1016/j.oret.2025.12.008
PubMed id: 41422860
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