Browse by author
Lookup NU author(s): Professor Roy Taylor
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2026.Purpose: To determine whether early gestational diabetes (GDM) differs from later GDM in maternal characteristics and perinatal outcomes. Methods: This is a secondary analysis of an energy-restricted dietary intervention in GDM (DiGest) randomized controlled trial. We compared maternal weight, glycemia, and pregnancy/neonatal outcomes between the early GDM (< 20 weeks, n = 118) and standard GDM diagnosis (21–28 weeks, n = 299) groups. Results: Early GDM was associated with higher antenatal (40 vs. 38 mmol/mol; p = 0.017) and postnatal HbA1c (38 vs. 36 mmol/mol; p = 0.002) and higher risk of diabetes/prediabetes postnatally (19 vs. 6%; p = 0.003). Despite higher medication requirements, perinatal outcomes did not differ. Lower gestational weight gain (2.5 vs. 5.3 kg, p = 0.003) and comparable glycemia at 36 weeks were found. Timing of diagnosis did not impact the effect of the DiGest intervention. Conclusion: Early GDM reflects more severe underlying hyperglycemia, but timely treatment and reduced gestational weight gain can offset adverse perinatal risks.
Author(s): Dib S, Luo N, Jones DL, Smith S, Taylor R, Murphy HR, Kusinski LC, Meek CL
Publication type: Article
Publication status: Published
Journal: Endocrine
Year: 2026
Volume: 91
Issue: 1
Online publication date: 16/02/2026
Acceptance date: 20/12/2025
Date deposited: 02/03/2026
ISSN (print): 1355-008X
ISSN (electronic): 1559-0100
Publisher: Springer
URL: https://doi.org/10.1007/s12020-025-04542-y
DOI: 10.1007/s12020-025-04542-y
Data Access Statement: The datasets generated during and/or analyzed in the current study are available from the corresponding author upon reasonable request.
PubMed id: 41697463
Altmetrics provided by Altmetric
