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Quartz crystal microbalance experiments reveal structural changes in the Staphylococcus aureus biofilm in the presence of savirin

Lookup NU author(s): Professor Mark GeogheganORCiD

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Abstract

Quartz-crystal microbalance with dissipation (QCM-D) experiments show that green-fluorescent protein labelled Staphylococcus aureus adsorption to a gold QCM electrode is similar for a certain incubation period (here, 6 h) in the presence and absence of the quorum sensing inhibitor, savirin. After this period, cells continue to adsorb in the absence of savirin, but in its presence biofilm formation is severely compromised, with significant changes in the viscoelastic properties of the layer being observed.

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Author(s): Hudzik EM, Parnell AJ, Petkov J, Geoghegan M

Publication type: Article

Publication status: Published

Journal: Results in Surfaces and Interfaces

Year: 2025

Volume: 19

Print publication date: 01/05/2025

Online publication date: 26/04/2025

Acceptance date: 20/04/2025

Date deposited: 17/03/2026

ISSN (electronic): 2666-8459

Publisher: Elsevier

URL: https://doi.org/10.1016/j.rsurfi.2025.100535

DOI: 10.1016/j.rsurfi.2025.100535

Data Access Statement: All data are included in the supporting material.

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