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Trypanosoma brucei cattle infections contain cryptic transmission‑adapted bloodstream forms at low parasitaemia

Lookup NU author(s): Dr Emma BriggsORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Publication metadata

Author(s): Larcombe SD, Paxton E, Vrettou C, Steketee PC, Matthews KR, Morrison LJ, Briggs EM

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2025

Volume: 16

Online publication date: 05/11/2025

Acceptance date: 25/09/2025

Date deposited: 08/04/2026

ISSN (electronic): 2041-1723

Publisher: Springer Nature

URL: https://doi.org/10.1038/s41467-025-64750-y

DOI: 10.1038/s41467-025-64750-y

Data Access Statement: The scRNA-seq data generated in this study have been deposited in the European Nucleotide Archive database under accession code PRJEB66078. The processed scRNA-seq data are available at zenodo.org under https://doi.org/10.5281/zenodo.14515536. All other data generated in this study are provided in the Supplementary Information/Source data file. The in vitro and mouse derived scRNA-seq data used in this study are available in the European Nucleotide Archive database under accession codes PRJEB41744 and PRJEB60851, respectively, and as processed data at zenodo.org under https://doi.org/10.5281/zenodo.14515536 Source data are provided with this paper.

PubMed id: 41193429


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Funding

Funder referenceFunder name
BBSRC Discovery Fellowship (BB/X009807/1)
MRC Career Development Award (MR/Z504786/1)
Sir Henry Wellcome Fellowship (218648/Z/19/Z)
Roslin Institute Pump Priming BBSRC grant (sub-award from BBS/E/RL/230002C)
United Kingdom Biotechnology and Biological Sciences Research Council (BBS/E/RL/230002C)
Wellcome Trust collaborative award (206815/Z/17/Z)
Wellcome Trust Investigator award (221717/Z/20/Z)

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