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Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells

Lookup NU author(s): Dr Nicholas BrittainORCiD, Ryan Nelson, Dr Beth Adamson, Dr Laura WalkerORCiD, Dr Ruaridh DuncanORCiD, Professor Graham SmithORCiD, Professor Craig RobsonORCiD, Dr Pasquale RescignoORCiD, Dr Sara LuzziORCiD, Dr Luke GaughanORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Publication metadata

Author(s): Brittain N, Paschalis A, Nelson R, Adamson B, Walker L, Duncan R, Smith GR, McGill S, Burchmore RJ, Bogdan D, Jiménez-Vacas JM, Welti J, Yuan W, Robson CN, Rescigno P, Luzzi S, Sharp A, de Bono J, Gaughan L

Publication type: Article

Publication status: Published

Journal: The Journal of Clinical Investigation

Year: 2026

Volume: 136

Issue: 7

Online publication date: 01/04/2026

Acceptance date: 30/01/2026

Date deposited: 16/04/2026

ISSN (print): 0021-9738

ISSN (electronic): 1558-8238

Publisher: American Society for Clinical Investigations

URL: https://doi.org/10.1172/JCI198264

DOI: 10.1172/JCI198264

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Funding

Funder referenceFunder name
Biomedical Research Centre funding to the Royal Marsden
C9380/A25138Cancer Research UK CRUK (open competition)
Cancer Research UK (Centre Programme grant)
Experimental Cancer Medicine Centre grant funding from Cancer Research UK and the Department of Health
Prostate Cancer Research (PCR-6955)
Prostate Cancer UK
The John Black Charitable Foundation and Prostate Cancer Foundation (18CHAL06 and 20YOUN17)
The Movember Foundation through the London Movember Centre of Excellence (CEO13_2-002)
The Wellcome Trust
The Ken Bell Bursary and JGW Patterson Foundation (12/21 NU009331)

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