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Whole genome sequencing in cerebral palsy: A UK paediatric pilot study

Lookup NU author(s): Dr Anna BasuORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


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Author(s): Ratnaike TE, Pierce HH, Coffey AJ, Dias JML, Kean IRL, Li E, More RP, Sumathipala DS, Bajracharya M, Kingsbury Z, Newington K, Rogers AS, Delon I, Downes K, deAlwis Y, Basu AP, Issa M, Kearney C, Khan AH, Marlow BP, Sansome A, Ahn J, Than AY, Lau T, Rajkumar R, Bentley DR, Bowdin S, Houlden H, Reid E, Humphray S, Rowitch D

Publication type: Article

Publication status: Published

Journal: The Lancet Regional Health - Europe

Year: 2026

Volume: 68

Print publication date: 01/09/2026

Online publication date: 30/07/2026

Acceptance date: 08/07/2026

Date deposited: 23/07/2026

ISSN (electronic): 2666-7762

Publisher: The Lancet Publishing Group

URL: https://doi.org/10.1016/j.lanepe.2026.101786

DOI: 10.1016/j.lanepe.2026.101786

Data Access Statement: De-identified WGS data, variant-level genetic and phenotypic data for this study from participants who have consented to share the data are available upon request from the corresponding author. To facilitate reproducibility, the complete R codebase used for dimensionality reduction, machine learning model training, and statistical evaluation has been made publicly available on University of Cambridge data repository at the following link: https://doi.org/10.17863/CAM.130807. Due to privacy and ethical considerations, the raw data are not publicly available. [continues at https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(26)00198-5/fulltext#sec-6 ]


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Funding

Funder referenceFunder name
Isaac Newton Trust
NIHR Cambridge Biomedical Research Centre (NIHR203312)
Rosetrees Trust

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