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Lookup NU author(s): Dr Kate HallsworthORCiD
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© Springer Nature Limited 2026. Metabolic dysfunction-associated steatotic liver disease, and the broader spectrum of steatotic liver disease (SLD), require tailored lifestyle interventions across different age groups, considering genetics, family involvement, and psychological, environmental and social factors. Clinical practice guidelines for adults typically recommend a uniform treatment approach, regardless of age-related considerations. However, different emphases might be needed for pregnant women, adults and the older age group (≥65 years of age). Moreover, metabolic health, and therefore liver health, are determined at a very early age and even in utero and infancy. Thus, the prevention and treatment of SLD should not be overlooked at these early life stages and should be specific for each stage of life. The life course approach is a comprehensive strategy that considers health needs across all stages of life, from infancy to older age. This Review puts the spotlight on these topics, creating a comprehensive age-chronological order overview of the literature, addressing gaps in knowledge, providing practical advice and highlighting age-related considerations, in contrast to a one-size-fits-all (ages) approach.
Author(s): Zelber-Sagi S, Ivancovsky-Wajcman D, Kugelmas C, Weinstein AA, Wong VW-S, Castera L, Moore JB, Mouzaki M, Hallsworth K, Paik JM, Schwimmer JB, Gerber LH, Younossi ZM
Publication type: Review
Publication status: Published
Journal: Nature Reviews Gastroenterology and Hepatology
Year: 2026
Pages: Epub ahead of print
Online publication date: 15/04/2026
Acceptance date: 13/03/2026
ISSN (print): 1759-5045
ISSN (electronic): 1759-5053
Publisher: Nature Research
URL: https://doi.org/10.1038/s41575-026-01198-5
DOI: 10.1038/s41575-026-01198-5
