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Lookup NU author(s): Professor Nicola PaveseORCiD
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© 2026 American Neurological Association.A research biologic definition and staging of neuronal alpha-synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, is critical toward improving clinical trial design and drug development. Neuronal synuclein disease, and the companion Integrated Staging System, are a biologic definition and staging system conceptualized by multiple stakeholders including academia, industry, advocacy organizations, and importantly, people with lived experiences. In large part, this was informed and enabled by the knowledge garnered from the Parkinson's Progression Markers Initiative. This review provides a historical perspective and details contributions from the Parkinson's Progression Markers Initiative, among others, that made this advancement possible. These include the key role it played in validation of an in vivo biomarker of neuronal alpha-synuclein, longitudinal characterization of dopaminergic dysfunction imaging, biospecimen collection and assays, comprehensive genetic characterization, and clinical phenotyping. In addition, the Parkinson's Progression Markers Initiative is generating and sharing data that will be used to address key gaps in knowledge, revisions, and future refinements of a biologic definition and staging of synucleinopathies. ANN NEUROL 2026.
Author(s): Chahine LM, Alcalay RN, Brown EG, Chowdhury S, Coffey CS, Foroud T, Frasier M, Galasko D, Merchant KM, Mollenhauer B, Tolosa E, Pavese N, Tropea TF, Marek K, Simuni T
Publication type: Editorial
Publication status: Published
Journal: Annals of Neurology
Year: 2026
Pages: Epub ahead of print
Online publication date: 06/05/2026
Acceptance date: 21/04/2026
ISSN (print): 0364-5134
ISSN (electronic): 1531-8249
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/ana.78249
DOI: 10.1002/ana.78249
PubMed id: 42089472
