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Lookup NU author(s): Professor Camille CarrollORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2026 The Author(s).Decentralised clinical trials (DCTs) can gather objective data in real-world settings through digital health technologies (DHTs) to obtain real-time measurements of clinical outcomes. However, such measurements remain infrequent in clinical trials of investigational medicinal products (CTIMPs). We review the decentralisation of CTIMPs, identify barriers to passive, real-time DHT use and recommend four solutions: a swift regulatory approval process for DHTs in clinical trials; development of specialised DHTs for CTIMPs; integration of human factors into DHT design for CTIMPs; and the adoption of data collection and transmission standards to enable decentralised CTIMPs to function effectively in patient homes.
Author(s): Douiri A, Alhnan MA, Asghar MR, Balaskas K, Benaouda F, Bolodeoku J, Campbell-Cooper C, Carroll C, Chen T, Dorricott K, Escudier T, Flohr C, Forbes B, Guy RH, Langouet S, Lockett A, Malek R, May A, McClelland GR, Nasereddin SM, Paredes AJ, Porkess S, Power EGM, Russell REK, Stephens R, Sailem H, Sebastia-Saez D, Sydes MR, Weinman J, Zhao Y, Jones SA
Publication type: Review
Publication status: Published
Journal: Drug Discovery Today
Year: 2026
Volume: 31
Issue: 3
Print publication date: 01/05/2026
Online publication date: 16/04/2026
Acceptance date: 02/04/2018
ISSN (print): 1359-6446
ISSN (electronic): 1878-5832
Publisher: Elsevier Ltd
URL: https://doi.org/10.1016/j.drudis.2026.104676
DOI: 10.1016/j.drudis.2026.104676
PubMed id: 42000125
Data Access Statement: Data availability. All information is available.
