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Pharmacological augmentation for people with treatment-resistant depression

Lookup NU author(s): Dr David CousinsORCiD, Professor Allan Young

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Abstract

© The Author(s), 2026. Published by Cambridge University Press on behalf of Royal College of Psychiatrists. Long-term pharmacological augmentation is central to care for treatment-resistant depression, yet until recently no adequately powered trials have examined it. With three such studies now published, we highlight the hope they offer for improving outcomes in this underserved population while highlighting caution in interpreting their collective findings without careful consideration of methodology and clinical context. We consider these issues and their implications for guiding more personalised treatment decisions aimed at sustained benefit in routine practice.

Publication metadata

Author(s): Strawbridge R, Nikolova VL, Browning M, Rucker J, Cowen PJ, Cousins DA, Young AH, Cleare AJ

Publication type: Article

Publication status: Published

Journal: British Journal of Psychiatry

Year: 2026

Pages: Epub ahead of print

Online publication date: 19/05/2026

Acceptance date: 02/04/2018

ISSN (print): 0007-1250

ISSN (electronic): 1472-1465

Publisher: Cambridge University Press

URL: https://doi.org/10.1192/bjp.2026.10673

DOI: 10.1192/bjp.2026.10673

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