Browse by author
Lookup NU author(s): Professor John-Paul TaylorORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2026.Lewy body disease (LBD) and Alzheimer’s disease (AD) are the most common causes of cognitive decline and dementia and are associated with characteristic alterations in resting-state electroencephalographic (rsEEG) activity. This multicenter exploratory study investigated periodic and aperiodic rsEEG features in patients with cognitive decline due to Lewy body disease (LBCD) and Alzheimer’s disease (ADCD), compared with cognitively unimpaired older adults (Nold), and examined the clinical relevance of these markers in LBCD. A total of 140 LBCD, 135 ADCD, and 118 Nold datasets from the PDWAVES archive underwent spectral parameterization to decompose rsEEG power spectra (1–30 Hz) into periodic peaks and aperiodic background activity. Both clinical groups showed a significant slowing of the individual alpha frequency (IAF), more pronounced in LBCD, along with reduced periodic alpha and beta power reflected in a lower vigilance index. The aperiodic exponent was elevated in both groups, and the aperiodic offset was also higher in LBCD, suggesting steeper spectral profiles consistent with increased inhibitory cortical tone. Within the LBCD group, poorer cognition was associated with higher low-frequency alpha power, whereas better cognition was predicted by higher high-frequency alpha power. A reduced vigilance index was associated with the presence of visual hallucinations, while no associations emerged for other symptoms. These findings suggest that combined periodic and aperiodic rsEEG features may provide relevant markers of altered vigilance regulation in LBCD. Future studies should evaluate whether these EEG markers can inform targeted interventions, such as neuromodulatory or audiovisual stimulation, to stabilize quiet-vigilance states and improve clinical outcomes.
Author(s): Carpi M, Afragola AP, De Bartolo M, Lopez S, Bolukbas B, Del Percio C, Henao Isaza V, Lizio R, Noce G, Barjami L, Carducci F, Soricelli A, Salvatore M, Giubilei F, Guntekin B, Yener G, Massa F, Arnaldi D, Fama F, Pardini M, Ferri R, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP, Hanoglu L, Yirikogullari H, Frisoni GB, Cuoco S, Barone P, Amboni M, Cappiello A, Bonanni L, D'Anselmo A, Biundo R, Cauzzo S, Fiorenzato E, Antonini A, D'Antonio F, Bruno G, Infarinato F, Romano P, Marziali S, De Pandis MF, Babiloni C
Publication type: Article
Publication status: Published
Journal: GeroScience
Year: 2026
Pages: epub ahead of print
Online publication date: 22/05/2026
Acceptance date: 13/05/2026
Date deposited: 08/06/2026
ISSN (print): 2509-2715
ISSN (electronic): 2509-2723
Publisher: Springer Science and Business Media Deutschland GmbH
URL: https://doi.org/10.1007/s11357-026-02325-5
DOI: 10.1007/s11357-026-02325-5
Data Access Statement: The datasets analyzed during the current study are not publicly available due to privacy considerations. De-identified data can be made available from the correspond ing author upon reasonable request
Altmetrics provided by Altmetric
