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Is molecular breast imaging suitable for use in UK breast cancer pathways? A qualitative study exploring healthcare professionals’ perspectives

Lookup NU author(s): Helen Elliott, Dr Joy AllenORCiD, Dr Nerys Forester, Dr Sara Graziadio, Dr Will Jones, Dr Clare Lendrem, Professor Mark PearceORCiD, Tim Powell, Dr Alison Bray, Dr Jason Scott

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. Objectives: To explore healthcare professionals’ perspectives on the potential role of molecular breast imaging (MBI) for breast cancer imaging and to inform future clinical study design and implementation. Design: Qualitative interview study. Setting: UK National Health Service (NHS) breast screening and diagnostic pathways. Participants: Purposively sampled stakeholders. Method: Semistructured interviews with key professional stakeholders explored potential MBI pathways and routes to adoption, including barriers and facilitators. Data were analysed thematically. Results: 22 participants were recruited between January 2020 and October 2021. Barriers to MBI adoption were identified at three levels: scan-related, system-level, and cultural within the screening programme. Overcoming these is likely necessary for implementation. A further theme highlighted the potential for MBI to improve screening in selected patient groups, contingent on addressing these barriers. Specifically, adoption would require advances in next-generation MBI systems, particularly reductions in radiation dose and scan time, alongside prospective clinical studies in UK populations to assess diagnostic accuracy. Conclusions: Once identified barriers are overcome, participants perceived that MBI could improve screening pathways, particularly for women with dense breast tissue.


Publication metadata

Author(s): Elliott H, Allen AJ, Forester ND, Graziadio S, Jones WS, Lendrem C, Pearce M, Powell T, Bray A, Scott J

Publication type: Article

Publication status: Published

Journal: BMJ Open

Year: 2026

Volume: 16

Issue: 6

Online publication date: 03/06/2026

Acceptance date: 29/04/2026

Date deposited: 24/06/2026

ISSN (print): 2044-6055

ISSN (electronic): 2044-6055

Publisher: BMJ Publishing Group

URL: https://doi.org/10.1136/bmjopen-2025-113676

DOI: 10.1136/bmjopen-2025-113676

Data Access Statement: Data are available upon reasonable request.

PubMed id: 42236092


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Funding

Funder referenceFunder name
Innovate UK Innovation in health and life sciences grant (ref 104296)
NIHR Newcastle In Vitro Diagnostics Co-operative (ref MIC-2016-014)

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