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Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom—Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme

Lookup NU author(s): Professor Sarah Slight

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.The Dame Barbara Windsor Dementia Goals Programme was launched by the UK Government to accelerate the development and delivery of new treatments for dementia. We present the recommendations from the Scientific Advisory Board, to enable timely access to therapies for the wider population, reducing health system burden while improving patient outcomes. The recommendations focus on three areas: (i) establishing a new dynamic national patient registry for clinical trial recruitment; (ii) the use of biomarkers to improve early and accurate diagnosis; and (iii) a framework for end-to-end implementation across the landscape of healthcare, research and regulators. A Brain Aging Registry for Biomarkers, Access to trials, Research and Adoption would support recruitment, monitoring, and personalized care. Embedding digital and biomarker innovations into routine care would improve personalized and equitable dementia services, with earlier diagnosis and more effective prevention. Robust patient and public involvement is required, to ensure transparency, trustworthiness, and meaningful participation.


Publication metadata

Author(s): McKernan RM, Rowe JB, John S, Karran E, Fachim HA, Imarisio S, Long R, Teunissen C, Slight SP, Mummery C, Hardy J

Publication type: Article

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2026

Volume: 22

Issue: 7

Online publication date: 05/07/2026

Acceptance date: 05/05/2026

Date deposited: 14/07/2026

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/alz.71621

DOI: 10.1002/alz.71621


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Funding

Funder referenceFunder name
Medical Research Council (MC_UU_00030/14; MR/T033371/1)
NIHR Cambridge Biomedical Research Centre (NIHR203312)
Wellcome Trust (220258)

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