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Lookup NU author(s): Amar RajgorORCiD, David Hamilton
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2026 The Author(s). Clinical Otolaryngology published by John Wiley & Sons Ltd. Objectives: Laryngeal cancer incidence has risen globally, yet survival outcomes have shown limited improvement over recent decades. This study evaluated contemporary outcomes across multiple centres in Northern UK and examined stage- and treatment-specific survival. Design: Multi-centre retrospective observational study. Setting and Participants: Data were collected for 2028 patients with biopsy-proven squamous cell carcinoma of the larynx treated with curative intent between 2015 and 2021 across six tertiary head and neck cancer centres (Newcastle, Glasgow, Liverpool, Sheffield, Leeds, and Middlesbrough). Main Outcome Measures: Overall survival (OS) and disease-specific survival (DSS) were estimated using Kaplan–Meier analysis and compared using log-rank testing. Results: Median follow-up was 40 months (mean age 66.8 years; 81% male). Overall mortality was 41% and disease-specific mortality 20%. Five-year OS declined with advancing stage: 72.0% (T1), 54.5% (T2), 50.6% (T3), and 45.2% (T4). In unadjusted analyses, surgery in T1 disease was associated with higher survival (5-year DSS 93.6% vs. 88.5%), while in advanced disease chemoradiotherapy was associated with the highest DSS (5-year DSS 70.2%), although differences were not statistically significant. No significant differences in DSS were observed across year of diagnosis (2015–2021). Conclusions: Survival outcomes for laryngeal cancer remain poor and have shown limited improvement over time. These findings provide important real-world insights into contemporary outcomes and highlight the need for earlier detection, prevention strategies, and prospective collaborative research to improve future outcomes.
Author(s): Rajgor A, Hurley R, Douglas CM, Paterson C, Moor J, Lester S, Davies K, O'Hara J, Inman G, Jones T, Hamilton DW, Northern Head & Neck Alliance
Publication type: Article
Publication status: Published
Journal: Clinical Otolaryngology
Year: 2026
Pages: Epub ahead of print
Online publication date: 08/07/2026
Acceptance date: 13/06/2026
Date deposited: 21/07/2026
ISSN (print): 1749-4478
ISSN (electronic): 1749-4486
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/coa.70138
DOI: 10.1111/coa.70138
Data Access Statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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