Browse by author
Lookup NU author(s): Abdullah MalikORCiD, Dr Sam Tingle, Steven White, Professor Sanjay PandanaboyanaORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2026 The Authors. Background: Minimally invasive left-sided pancreatectomy (MIS-LP) is increasingly adopted for resection of grade 1 and 2 pancreatic neuroendocrine tumours (PNETs), but its oncological equivalence to open left-sided pancreatectomy (O-LP) remains to be fully evaluated. Methods: We conducted a retrospective cohort study using SEER-Medicare data (2010–2019) including all patients who underwent left-sided pancreatectomy (LP) for PNETs. A multilevel Cox regression model was used to to provide adjusted hazard ratios (HR) for overall survival (OS) and cancer-specific survival (CSS) when comparing between MIS-LP and O-LP. A 6-month landmark survival analysis was performed to account for early postoperative deaths. Results: A total of 772 patients were included, with 257 (33.3%) undergoing MIS-LP. Six-hundred-and-seventy-two patients had grade 1, and 100 patients had grade 2 PNETs. MIS-LP was associated with better OS (HR 0.48, 95% CI 0.26-0.86, P=0.014) and CSS (HR 0.35, 95% CI 0.14-0.88, P=0.026). In the 6-month landmark analysis, O-LP was associated with similar OS and CSS to MIS-LP. Conclusion: MIS-LP is associated with improved early survival compared to O-LP in patients with low- to intermediate-grade PNETs.
Author(s): Malik AK, Chang Y-HH, Tingle SJ, White SA, Qadan M, Fong ZV, Pandanaboyana S
Publication type: Article
Publication status: Published
Journal: HPB
Year: 2026
Pages: Epub ahead of print
Online publication date: 12/07/2026
Acceptance date: 04/07/2026
Date deposited: 03/08/2026
ISSN (print): 1365-182X
ISSN (electronic): 1477-2574
Publisher: Elsevier BV
URL: https://doi.org/10.1016/j.hpb.2026.07.003
DOI: 10.1016/j.hpb.2026.07.003
Altmetrics provided by Altmetric
