Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases

Konuri, A; Leal, GC; Zebarjadi, N; Habich, A; Castellanos-Perilla, N; Gonzalez, MC; Taylor, J-P; Firbank, M; Alcolea, D; Bejanin, A; Segers, K; Benoit, F; Isik, AT; Samanci, B; Cháfer-Pericás, C; Wade-Martins, R; Hu, MTM; Bhome, R; Dobreva, I; Walker, Z; Aarsland, D; Westman, E; Ferreira, D; Halliday, G; Lewis, SJG; Weil, RS; Landin-Romero, R; Lambert, C; Oxtoby, NP; Matar, E

doi:10.1016/j.ebiom.2026.106400

Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases

Lookup NU author(s): Professor John-Paul Taylor ORCiD, Dr Michael Firbank ORCiD, Dr Dag Aarsland

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Author(s): Konuri A, Leal GC, Zebarjadi N, Habich A, Castellanos-Perilla N, Gonzalez MC, Taylor J-P, Firbank M, Alcolea D, Bejanin A, Segers K, Benoit F, Isik AT, Samanci B, Cháfer-Pericás C, Wade-Martins R, Hu MTM, Bhome R, Dobreva I, Walker Z, Aarsland D, Westman E, Ferreira D, Halliday G, Lewis SJG, Weil RS, Landin-Romero R, Lambert C, Oxtoby NP, Matar E

Publication type: Article

Publication status: Published

Journal: eBioMedicine

Year: 2026

Volume: 131

Print publication date: 01/09/2026

Online publication date: 05/08/2026

Acceptance date: 06/07/2026

Date deposited: 26/08/2026

ISSN (electronic): 2352-3964

Publisher: The Lancet Publishing Group

URL: https://doi.org/10.1016/j.ebiom.2026.106400

DOI: 10.1016/j.ebiom.2026.106400

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Funding

Funder reference	Funder name
Institute of Health Carlos III (ISCIII), Spain, PI18/00435, PI22/00611, INT19/00016, INT23/00048 and PI25/00422
Michael J. Fox Foundation
Lewy Body Society
Medical Research Council (MR/R006504/1)
National Health and Medical Research Council (NHMRC) grant (2008565)
Monument Trust Discovery Award from Parkinson’s UK (J-1403)
NHMRC Investigator grant (2034292)
NIHR Newcastle Biomedical Research Centre
NIA/NIH Grant U24 AG072122
Parkinson’s UK
The Australian Rotary Health/Rotary Club of Belconnen 50th Anniversary PhD Scholarship (SC4968)
the Department of Health Generalitat de Catalunya PERIS programme SLT006/17/125, SLT042/ 25/000034
the Lewy Body Society
University of Sydney Horizon Fellowship
Wellcome Career Development Award (#225263/Z/22/Z)
UKRI Medical Research Council (MR/S03546X/1, MR/X024288/1)
Wellcome Trust [227341/Z/23/Z]

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Data-driven trajectories of atrophy explain clinical heterogeneity across Lewy body diseases

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