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Utilising high throughput technologies for the determination of the reaction network of the ʟ-proline catalysed aldol reaction

Lookup NU author(s): Dr Katarina Novakovic, Dr Mark Willis, Professor Allen Wright


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The objective of this work is to facilitate the determination of a reliable reaction network for the l-proline catalysed aldol reaction using high throughput technologies (HTT). The availability of reliable reaction network is fundamental to predictive kinetic modelling including scale up, replacing a batch process with a continuous one, optimisation, thermal safety, process simulation, etc. The extent to which HTT experiments may be used to provide the necessary quantitative understanding of both physical and chemical phenomena of the system studied is assessed through a four stage development programme. For this particular system it is shown that, in conjunction with appropriate experimental designs, meaningful data streams for mechanistic/kinetic studies can be generated. The experimental data allowed a reaction network for the l-proline catalysed aldol reaction to be proposed and verified through a kinetic modelling exercise.

Publication metadata

Author(s): Novakovic K, Willis MJ, Wright AR

Publication type: Article

Publication status: Published

Journal: Clean Technologies and Environmental Policy

Year: 2008

Volume: 10

Issue: 2

Pages: 155-163

ISSN (print): 1618-954X

ISSN (electronic): 1618-9558

Publisher: Springer


DOI: 10.1007/s10098-007-0136-1


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