Browse by author
Lookup NU author(s): Dr Stella-Maria Paddick, Dr Catherine DotchinORCiD, Professor Richard Walker, Professor Raj KalariaORCiD, Dr Rufus Akinyemi
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© The Author(s) 2026.Alzheimer’s disease and related dementia (ADRD) represents a growing public health burden, especially in low- and middle-income countries. Yet, most studies focus on Non-Hispanic white (NHW) populations from high-income countries. This study investigates plasma proteomic signatures associated with amyloid pathology in African populations. Nigerian older adults from the VALIANT study and participants from a Tanzanian study, with available biomarker quantification in plasma are employed. For proteomic comparison, participants from the Canadian TRIAD cohort are included, capturing a distinct population. Here, we show that multiple proteins are differentially abundant in the plasma of p-tau217-positive individuals and in the different cognitive groups, with findings largely consistent amongst African cohorts. Comorbidities are significantly associated with protein levels and differences in plasma biomarkers levels are found between sexes. Lastly, VALIANT and TRIAD show both shared and unique protein profiles in relation to amyloid-pathology. These findings support the utility of fluid biomarkers in ADRD in African populations.
Author(s): Pola I, Akinyemi T, Tan K, Olalusi O, Traichel W, Giacomucci G, Yaria J, Rahmouni N, Ogunde G, Oguntiloye O, Macedo AC, Fagbemi A, Cadmus E, Therriault J, Popoola F, Paddick S-M, Dotchin C, Kisoli A, Walker R, Ogunronbi M, Olujobi D, Famuyiwa O, Akinyemi J, Owolabi M, Udeh-Momoh CT, Ladokun O, Griswold A, Romero-Ortuno R, Pericak-Vance M, Ogunniyi A, Debette S, Lawlor B, Ashton NJ, Kalaria R, Zetterberg H, Rosa-Neto P, Akinyemi RO, Benedet AL
Publication type: Article
Publication status: Published
Journal: Nature Communications
Year: 2026
Volume: 17
Issue: 1
Online publication date: 01/07/2026
Acceptance date: 18/06/2026
Date deposited: 25/08/2026
ISSN (electronic): 2041-1723
Publisher: Nature Research
URL: https://doi.org/10.1038/s41467-026-74971-4
DOI: 10.1038/s41467-026-74971-4
Data Access Statement: Source data are provided with this file. Pseudonymized participant-level data supporting the findings of this study can be shared upon request by contacting the corresponding author, Rufus Akinyemi. Data access will be provided in accordance with applicable ethical approvals, participant consent, and local data protection regulations. Source data are provided with this paper. https://www.nature.com/articles/s41467-026-74971-4#Sec19
PubMed id: 42386726
Altmetrics provided by Altmetric
