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Steatotic liver disease trajectory: A holistic EASL guidance on the multidisciplinary approach to screening and patient management

Lookup NU author(s): Laura HaighORCiD, Dr Kate HallsworthORCiD, Professor Dina Tiniakos

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2026 The Authors. Steatotic liver disease (SLD) is a spectrum of highly prevalent liver diseases encountered at many different healthcare levels. Awareness about metabolic dysfunction-associated SLD (MASLD), MetALD (MASLD and increased alcohol intake) and ALD (alcohol-related liver disease) is increasing beyond hepatology, as reflected by the various SLD guidelines issued by scientific societies from different disciplines, including endocrinology. The guidance presented here aims to improve cross-disciplinary knowledge and know-how by providing guidance to healthcare professionals from a global, holistic, multi-society and multi-stakeholder perspective. The patient trajectory was used as an overarching anchor point to ensure uniform guidance at all points along the SLD spectrum, with the ultimate goal of improving patient identification and optimising care. This consensus guidance covers patient identification and risk stratification, relevant cross-disciplinary primary and secondary care approaches, referral to and from tertiary care and strategies for disease management and monitoring.


Publication metadata

Author(s): Brouwer WP, Vonghia L, Thiele M, Schattenberg J, Anastasiou F, Beckmann S, Bugianesi E, Castera L, Caussy C, Cordie A, De Bruyne R, Fabrellas N, Fruhbeck G, Gadi Z, Gastaldelli A, Geerts A, Haigh L, Hallsworth K, Holleboom A, Lackner C, Lazarus JV, Mendive J, Michel M, Mooney V, Ratziu V, Roden M, Sanyal AJ, Spearman WC, Stefanescu H, Tiniakos D, Tsochatsis E, Willemse J, Zannad F, Zelber-Sagi S, Krag A, Francque S

Publication type: Review

Publication status: Published

Journal: JHEP Reports

Year: 2026

Volume: 8

Issue: 9

Print publication date: 01/09/2026

Online publication date: 25/02/2026

Acceptance date: 24/02/2026

ISSN (electronic): 2589-5559

Publisher: Elsevier B.V.

URL: https://doi.org/10.1016/j.jhepr.2026.101798

DOI: 10.1016/j.jhepr.2026.101798

Data Access Statement: Supplementary data included with the article.


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