Browse by author
Lookup NU author(s): Dr Anjam Khan, Professor Kate Gould, Professor Anthony De SoyzaORCiD, Professor Antonio Molinaro
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens for humans especially in cystic fibrosis patients. Lipopolysaccharide (LPS) molecules are potent virulence factors of Gram-negative bacteria organisms essential for bacterial survival. A complete analysis of the bacterial lipopolysaccharide structure to function relationship is required to understand the chemical basis of the inflammatory process. We have therefore investigated the structures of lipopolysaccharides from clonally identical Burkholderia multivorans strains (genomovar II) isolated pre- and post-lung transplantation through compositional analysis, mass spectrometry, and 2D NMR spectroscopy. We tested the LPS proinflammatory activity as a stimulant of human myelomonocytic U937 cell cytokine induction and assessed TLR4/MD2 signaling. Marked changes between the paired strains were found in the lipid A-inner core region. Such structural variations can contribute to the bacterial survival and persistence of infections despite the loss of a CF milieu following lung transplantation. PMID: 18684854 [PubMed - indexed for MEDLINE]
Author(s): Ieranò T, Silipo A, Sturiale L, Garozzo D, Brookes H, Khan CM, Bryant C, Gould FK, Corris PA, Lanzetta R, Parrilli M, De Soyza A, Molinaro A
Publication type: Article
Publication status: Published
Journal: Glycobiology
Year: 2008
Volume: 18
Issue: 11
Pages: 871-881
ISSN (print): 0959-6658
ISSN (electronic): 1460-2423
Publisher: Oxford University Press
URL: http://dx.doi.org/10.1093/glycob/cwn074
DOI: 10.1093/glycob/cwn074
Altmetrics provided by Altmetric
