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Lookup NU author(s): Dr Julian Venables
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This review concentrates on the clear cases where knocking out a gene in mice has caused male infertility and thus comes near to proving that the gene plays a role in the development of sperm. Knockout mice have been created with primary defects at every stage of spermatogenesis thus creating a framework for decoding the genetic hierarchy that causes male germ cell differentiation. As well as defining essential genes in vivo experiments have defined promoter and untranslated sequences responsible for the expression of proteins at all the spermatogenic stages. In conclusion knockout mice remain the ultimate test of spermatogenic hypotheses as well as providing detailed information about this complex process.
Author(s): Venables JP, Cooke HJ
Publication type: Article
Publication status: Published
Journal: Journal of Endocrinological Investigation
ISSN (print): 0391-4097
ISSN (electronic): 1720-8386
Publisher: Editrice Kurtis s.r.l.