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Lessons from knockout and transgenic mice for infertility in men

Lookup NU author(s): Dr Julian Venables


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This review concentrates on the clear cases where knocking out a gene in mice has caused male infertility and thus comes near to proving that the gene plays a role in the development of sperm. Knockout mice have been created with primary defects at every stage of spermatogenesis thus creating a framework for decoding the genetic hierarchy that causes male germ cell differentiation. As well as defining essential genes in vivo experiments have defined promoter and untranslated sequences responsible for the expression of proteins at all the spermatogenic stages. In conclusion knockout mice remain the ultimate test of spermatogenic hypotheses as well as providing detailed information about this complex process.

Publication metadata

Author(s): Venables JP, Cooke HJ

Publication type: Article

Publication status: Published

Journal: Journal of Endocrinological Investigation

Year: 2000

Volume: 23

Issue: 9

Pages: 584-591

ISSN (print): 0391-4097

ISSN (electronic): 1720-8386

Publisher: Editrice Kurtis s.r.l.


Notes: 0391-4097 Journal Article Review Review, Tutorial