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The roles of RNA-binding proteins in spermatogenesis and male infertility

Lookup NU author(s): Dr Julian Venables

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Abstract

RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.

Publication metadata

Author(s): Venables JP; Eperon I

Publication type: Article

Publication status: Published

Journal: Current Opinion in Genetics & Development

Year: 1999

Volume: 9

Issue: 3

Pages: 346-354

Print publication date: 13/08/1999

ISSN (print): 0959-437X

ISSN (electronic): 1879-0380

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/S0959-437X(99)80052-5

DOI: 10.1016/S0959-437X(99)80052-5

Notes: 0959-437x Journal Article Review Review, Tutorial

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